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Prescription treatment for adults with Dupuytren's contracture when a "cord" can be felt

Take the first step toward learning more about treatment with XIAFLEX® by talking to a specialist nearest you.

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USE THE SPECIALIST LOCATOR

Enter your ZIP Code in the search tool below to find specialists* in your area who are experienced in administering XIAFLEX®.

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If you're an HCP, you also have the option to use the HCP-specific website.

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*Endo Pharmaceuticals Inc. maintains a list of physicians who have received the necessary training and have experience in injecting XIAFLEX® 12 or more times over the last 12 months as designated by a blue check mark. This XIAFLEX® usage information will be updated on a rolling monthly basis.

Physicians who have received the necessary training, but have not administered at least 12 injections of XIAFLEX® over this time frame, are also listed on this website, unless they have administered <1 injection within the last 6 months, in which case they will not be listed.

Physicians listed on this website are not affiliated with Endo Pharmaceuticals Inc., and do not pay to be on this list or to be designated as experienced users of XIAFLEX®.

The Specialist Locator is a directory of physicians who have notified Endo Pharmaceuticals that they are certified in injection procedures of the hand and in the treatment of Dupuytren's contracture. Inclusion of a physician in the Specialist Locator does not constitute a referral, recommendation, endorsement, or verification of credentials, qualifications, or abilities of the physician listed. Conversely, the absence of a physician’s name and information should not be construed as a negative comment from Endo Pharmaceuticals about the physician’s credentials, qualifications, or abilities.

Endo Pharmaceuticals shall not be liable for any harm resulting from your reliance on information contained in the Specialist Locator.

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Important Safety Information for XIAFLEX®

Do not receive XIAFLEX® if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®.

XIAFLEX® can cause serious side effects, including:

  • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX® may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit
  • Nerve injury or other serious injury of the hand. Call your healthcare provider right away if you get numbness, tingling, increased pain, or tears in the skin (laceration) in your treated finger or hand after your injection or after your follow-up visit
  • Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX® because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:
    • hives
    • swollen face
    • breathing trouble
    • chest pain
    • low blood pressure
    • dizziness or fainting
  • Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.

Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

The most common side effects with XIAFLEX® for the treatment of Dupuytren’s contracture include:

  • swelling of the injection site or the hand
  • bruising or bleeding at the injection site
  • pain or tenderness of the injection site or the hand
  • swelling of the lymph nodes (glands) in the elbow or armpit
  • itching
  • breaks in the skin
  • redness or warmth of the skin
  • pain in the armpit

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

What is XIAFLEX®?

XIAFLEX® is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. It is not known if XIAFLEX® is safe and effective in children under the age of 18.

Please see the full Prescribing Information, including Medication Guide.