compensated for their time
Dupuytren’s contracture is a hand condition that can occur in one or both hands. Dupuytren’s contracture is caused by a buildup of collagen that forms a rope-like cord beneath the skin of the palm. As a progressive condition, it may worsen over time, and may eventually limit your ability to move or straighten your fingers.
The short answer: collagen.
Collagen is a protein with a fiber-like structure that is found in connective tissue.
The longer answer: Dupuytren’s is a disease that causes a buildup of collagen beneath the surface of the skin of the hand. It may start to form a nodule that appears as a lump below the skin or a dimpling of the skin called pitting.*
As the collagen thickens, it can develop into a rope-like cord that extends from the palm to the finger. The tightening of the cord can make fingers bend inward toward the palm, which, over time, can potentially limit how a person moves or straightens their fingers.
Not being able to lay your hand flat
A rope-like cord that extends from the palm to the finger
The inability to move or straighten your fingers
Difficulty doing daily tasks such as gripping a mug, washing your face, brushing your hair, or shaking hands because of a contracted finger or fingers
Yes, Dupuytren’s contracture most commonly affects the ring and pinky fingers, though it can affect any finger or multiple fingers on one or both hands.
It also most commonly affects:
†MP=metacarpophalangeal; PIP=proximal interphalangeal.
While anyone can have Dupuytren’s contracture and the exact cause is unknown, some people are more likely to develop it than others. Some risk factors include:
Risk Factor 1
Age—More common in people over 40
Risk Factor 2
Gender—More likely to occur in men
Risk Factor 3
Family History—Often runs in families
Risk Factor 4
Family Background—More common in people with Northern European ancestry (“Viking Disease”)
Risk Factor 5
Smoking—May increase risk
Risk Factor 6
Diabetes—Also believed to increase risk
If you’re seeing any of the changes in your hand listed above, have a rope-like cord, and/or cannot lay your hand flat against a tabletop, you should see a Hand Specialist.
XIAFLEX is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. It is not known if XIAFLEX is safe and effective in children under the age of 18.
Do not receive XIAFLEX if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX.
Before receiving XIAFLEX, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.
The most common side effects with XIAFLEX for the treatment of Dupuytren’s contracture include:
Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX. For more information, ask your healthcare provider or pharmacist.
Click for full Prescribing Information, including Medication Guide.