XIAFLEX®—the only FDA-approved nonsurgical treatment for Dupuytren’s contracture when a “cord” can be felt

Actual patients
compensated for their time

Xiaflex Patient Silhouettes

It is estimated that more than 190,000 adult patients with Dupuytren’s contracture have been prescribed XIAFLEX.*

83% (206 out of 249) of patients were satisfied with XIAFLEX compared with 30% (38 out of 125) of patients with placebo.†

Find a Hand Specialist trained in XIAFLEX near you

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  1. How do I know if I have Dupuytren’s contracture?

    How do I know if I have Dupuytren’s Dupuytren’s contracture?

    One way to test yourself for Dupuytren’s contracture is to see if you can lay your hand flat on a surface, like a tabletop. This is known as a Tabletop Test. If you can’t lay your hand flat, you should talk with a Hand Specialist, because you may have Dupuytren’s contracture.

    They can provide an official diagnosis, help you make a treatment plan, or discuss treatment options like XIAFLEX.

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  2. How do I know if  XIAFLEX may be right for me?

    How do I know if  XIAFLEX may be right for me?

    XIAFLEX is used to treat contractures ranging from less severe to more severe.‡ If your finger is contracted toward your palm and you have a “cord” that can be felt, you may be a candidate for XIAFLEX.

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  3. How do I find a Hand Specialist trained in XIAFLEX?

    How do I find a Hand Specialist trained in XIAFLEX?

    Not all Hand Specialists are trained to provide nonsurgical XIAFLEX injections. That’s why it’s important to self-advocate for the treatment you’re looking for. To find a Hand Specialist trained in XIAFLEX near you, use our XIAFLEX Hand Specialist Locator.

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WHAT IS XIAFLEX®?

XIAFLEX is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. It is not known if XIAFLEX is safe and effective in children under the age of 18.

IMPORTANT SAFETY INFORMATION FOR XIAFLEX

Do not receive XIAFLEX if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX.

XIAFLEX can cause serious side effects, including:

  • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit
  • Nerve injury or other serious injury of the hand. After finger procedures, some people developed tears in the skin (lacerations), and local skin and soft-tissue necrosis (death of skin cells). Some lacerations and necrosis required skin grafting, or other surgery including amputation. Call your healthcare provider right away if you get numbness, tingling, increased pain, or tears in the skin (laceration) in your treated finger or hand after your injection or after your follow-up visit
  • Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX:
    • hives
    • swollen face
    • breathing trouble
    • chest pain
    • low blood pressure
    • dizziness or fainting
  • Fainting. Fainting (passing out) or near fainting can happen in people who receive XIAFLEX, especially following finger procedures
    If you have dizziness or feel faint after receiving XIAFLEX, lie down until the symptoms go away.
  • Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX may not be right for you.

Before receiving XIAFLEX, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

The most common side effects with XIAFLEX for the treatment of Dupuytren’s contracture include:

  • swelling of the injection site or the hand
  • bruising or bleeding at the injection site
  • pain or tenderness of the injection site or the hand
  • swelling of the lymph nodes (glands) in the elbow or armpit
  • itching
  • breaks in the skin
  • redness or warmth of the skin
  • pain in the armpit

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX. For more information, ask your healthcare provider or pharmacist.

Click for full Prescribing Information, including Medication Guide.

Actual patients compensated for their time.

*From February 2010 through May 2022.

†In 2 clinical studies, patients were asked to rate their satisfaction with treatment on Day 90 as “very satisfied,” “quite satisfied,” “neither satisfied nor dissatisfied,” “quite dissatisfied,” or “very dissatisfied.” For data analysis, “satisfied” includes patients who chose “very satisfied” or “quite satisfied.”

In these 2 clinical studies, patients received up to 3 injections of XIAFLEX (collagenase clostridium histolyticum) or placebo into a cord that could be felt on Days 0, 30, and 60. About 24 hours after each injection, patients had a finger extension procedure and were fitted with a splint to wear at bedtime for up to 4 months. Patients also performed finger exercises every day.

In these 2 studies, 60% of patients had a straight or nearly straight finger 30 days after the last injection on Days 30, 60, or 90 after up to 3 XIAFLEX injections and finger extension procedures compared with 6% of patients who received placebo.

The most common side effects with XIAFLEX in these studies were swelling of the injected hand and bruising or bleeding at the injection site.

‡In clinical trials, XIAFLEX was used to treat 20°-100° metacarpophalangeal (MP) joint contractures and 20°-80° proximal interphalangeal (PIP) joint contractures.