Actual patients
compensated for their time
XIAFLEX is an FDA-approved nonsurgical injectable treatment for adults with Dupuytren’s contracture when a “cord” can be felt. XIAFLEX should be injected by a healthcare provider experienced in injection procedures of the hand and in treating people with Dupuytren’s contracture.
Please see below for the most common side effects.
XIAFLEX is injected into the collagen “cord” that is causing the contracture. After injection, the XIAFLEX enzymes are thought to attach to the collagen that makes up the rope-like cord in the palm, unwinding the collagen and eventually, breaking it down.
The mechanism of action of XIAFLEX in Dupuytren’s contracture is not fully understood.
Watch the video to see how XIAFLEX is thought to work.
XIAFLEX is an injection given in a doctor’s office by a Hand Specialist with XIAFLEX training. Treatment doesn’t require general anesthesia, and up to 2 cords in 1 hand may be treated during 1 office visit.
Dupuytren’s contracture may come back—no matter what treatment option you use. If your contracture returns after treatment, your Hand Specialist will let you know if XIAFLEX may be used again.
Studies show that prescription XIAFLEX, along with a finger extension procedure, may help straighten or nearly straighten finger(s) affected by Dupuytren’s contracture and may improve range of motion after up to 3 injections.
XIAFLEX may help contractures ranging from less severe to more severe, multiple contractures (up to 2 cords), or contractures that have come back.
Explore the images to see a few results from people with Dupuytren’s contracture who received XIAFLEX.
Step 01
Call your Hand Specialist right away if you have any serious side effects.
Step 02
Follow the Hand Specialist’s instructions on when you can start doing normal activities with your injected hand.
Step 03
XIAFLEX is considered safe for the treatment of Dupuytren’s contracture in adults over 18 with a “cord” that can be felt.
XIAFLEX can cause serious side effects such as tendon rupture, ligament damage, and/or nerve injury or other serious injury of the hand; hypersensitivity reactions, including anaphylaxis; fainting, and increased chance of bleeding in certain cases.
Call the Hand Specialist right away if you have:
If you have dizziness or feel faint after receiving XIAFLEX, lie down until the symptoms go away.
The most common side effects with XIAFLEX for the treatment of Dupuytren’s contracture include: swelling of the injection site or the hand; bruising or bleeding at the injection site; pain or tenderness of the injection site or the hand; swelling of the lymph nodes (glands) in the elbow or armpit; itching; breaks in the skin; redness or warmth of the skin; and pain in the armpit.
Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible XIAFLEX side effects.
For more information, ask your healthcare provider or pharmacist.
For most eligible patients with commercial insurance plans, there is a $0 copay for XIAFLEX injections when you use the XIAFLEX Copay Assistance Program.*
How much you pay for XIAFLEX will depend on your health benefits or insurance coverage. The XIAFLEX Copay Assistance Program can cover up to $1,200 of your out-of-pocket costs for each vial.
Learn more about savings with XIAFLEX and how to qualify for the XIAFLEX Copay Assistance Program on our Resources page.
XIAFLEX is only available by prescription. Visit a Hand Specialist trained in XIAFLEX and ask about XIAFLEX for your Dupuytren’s contracture.
If you need to find a Hand Specialist, you can use our Hand Specialist Locator below.
Some helpful hints while your results load:
XIAFLEX is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. It is not known if XIAFLEX is safe and effective in children under the age of 18.
Do not receive XIAFLEX if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX.
Before receiving XIAFLEX, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.
The most common side effects with XIAFLEX for the treatment of Dupuytren’s contracture include:
Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX. For more information, ask your healthcare provider or pharmacist.
Click for full Prescribing Information, including Medication Guide.