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Prescription treatment for adults with Dupuytren's contracture when a "cord" can be felt

Have you been living with your Dupuytren's contracture with a "cord" that can be felt? It’s important to know what to ask your healthcare professional (HCP) and what to expect before, during, and after treatment with XIAFLEX®.


XIAFLEX® should be injected into a cord by a specialist who is experienced in injection procedures of the hand and treating people with Dupuytren’s contracture.


A specialist will inject XIAFLEX®

  • Your HCP will inject XIAFLEX® into the cord that is causing your finger to bend. XIAFLEX® is injected in 3 locations of the cord during each injection procedure
  • If you have more than 1 contracture, your HCP may give you 2 injections in 1 of your hands during your visit

What to expect:

  • After an injection of XIAFLEX®, your affected hand will be wrapped with a bandage and your HCP will instruct you on how to care for your hand
  • You will need to elevate your hand until bedtime
  • You will be asked to limit movement of the treated finger(s). Do not bend or straighten the fingers of your injected hand until your HCP says it is okay. Do not try to straighten the treated finger(s) yourself

Call your HCP right away if you have:

  • signs of infection after your injection, such as fever, chills, increased redness, or swelling
  • numbness or tingling in the treated finger(s)
  • trouble bending the injected finger(s) after the swelling goes down

Your HCP may need to extend your finger(s)

  • Return to your HCP’s office for a follow-up visit as directed about 1 to 3 days after your XIAFLEX® injection
  • If you still have the cord, your HCP may try to extend the treated finger(s) to "break" the cord and try to straighten your finger(s). If your HCP cannot "break" the cord, you may need to return for additional injection procedures (up to 3 times total, 4 weeks apart)
  • Your HCP will provide a splint to wear on the treated finger(s)

Your HCP will check on your progress

  • Return to your HCP about 30 days after the procedure to check on your progress

Caring for your treated hand

  • Do finger exercises each day, as instructed by your HCP
  • Wear the splint at bedtime as instructed by your HCP to keep your finger(s) straight
  • Follow your HCP’s instructions about when you can start your normal activities with the injected hand


Is XIAFLEX® right for you?

The following questions can help you and your HCP decide. To take it with you to your next appointment, you can also download the guide.

  • Do I have a "cord" that can be felt?
  • I've had previous surgeries. Can I still be treated with XIAFLEX®?
  • Am I a candidate for treatment with XIAFLEX®?
  • Are you trained/certified to administer XIAFLEX®? If not, can you refer me to someone who is?
  • How does XIAFLEX® work?
  • How will I receive XIAFLEX®?
  • How many injections of XIAFLEX® are required?
  • Are there any incisions required to administer XIAFLEX®?
  • What are the possible side effects of XIAFLEX®?
  • Does my insurance cover XIAFLEX®?
See More

Important Safety Information for XIAFLEX®

Do not receive XIAFLEX® if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®.

XIAFLEX® can cause serious side effects, including:

  • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX® may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit
  • Nerve injury or other serious injury of the hand. Call your healthcare provider right away if you get numbness, tingling, increased pain, or tears in the skin (laceration) in your treated finger or hand after your injection or after your follow-up visit
  • Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX® because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:
    • hives
    • swollen face
    • breathing trouble
    • chest pain
    • low blood pressure
    • dizziness or fainting
  • Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.

Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

The most common side effects with XIAFLEX® for the treatment of Dupuytren’s contracture include:

  • swelling of the injection site or the hand
  • bruising or bleeding at the injection site
  • pain or tenderness of the injection site or the hand
  • swelling of the lymph nodes (glands) in the elbow or armpit
  • itching
  • breaks in the skin
  • redness or warmth of the skin
  • pain in the armpit

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

What is XIAFLEX®?

XIAFLEX® is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. It is not known if XIAFLEX® is safe and effective in children under the age of 18.

Please see the full Prescribing Information, including Medication Guide.