XIAFLEX® injection selectively targets collagen found in Dupuytren’s contracture cords1
XIAFLEX® works to help disrupt the cord without requiring an incision1*
Please see the full Prescribing Information, including Medication Guide.
Enzymatic Disruption
Two highly selective microbial collagenases (AUX-I and AUX-II) work together to disrupt types I and III collagen found in the cords without damaging nerves, arteries, or large veins containing type IV collagen.1

Binds
Selects and binds to the collagen molecule

Unwinds
Hydrolyzes the triple helix, exposing peptide bonds2

Lyses
Cleaves the peptide bonds
- There are no clinical data regarding relative contributions of the individual collagenases to the efficacy of XIAFLEX® in the treatment of Dupuytren’s contracture1
- In these studies, nonfibrillar type IV collagen was affected, causing collagen lysis in small veins1
*Promptly evaluate signs and symptoms of serious injury to the injected finger/hand, as surgical intervention may be required.1