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Prescription treatment for adults with Dupuytren's contracture when a "cord" can be felt

Wondering if XIAFLEX® is right for you? XIAFLEX® is the first and only FDA-approved nonsurgical treatment for adults with Dupuytren's contracture when a "cord" can be felt.

ASK YOUR HCP ABOUT A NONSURGICAL TREATMENT OPTION

What is XIAFLEX®?

XIAFLEX® is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. XIAFLEX® is injected directly into the cord that is causing your finger to be bent.

Healthcare professionals hand over patient's hand

XIAFLEX® is administered

  • In your HCP's office
  • By a hand specialist with training specifically for XIAFLEX®
  • With no general anesthesia required

XIAFLEX® should be injected into a cord by a specialist who is experienced in injection procedures of the hand and treating people with Dupuytren’s contracture. XIAFLEX® can cause serious side effects such as tendon rupture or ligament damage.

Your HCP may consider treatment with XIAFLEX® if you have:

  • Contractures ranging from less severe to more severe
  • Multiple contractures in 1 hand. Up to 2 cords in 1 hand may be treated during 1 office visit.
  • Contractures that have come back

How XIAFLEX® works

The enzymes in XIAFLEX® may break down the collagen in the cord. At a follow-up visit 1 to 3 days after the injection, if you still have the cord, your HCP may try to extend the finger to "break" the cord and try to straighten your finger. Your HCP may use local anesthetic during this procedure.

Demonstrated in clinical studies

Studies show that prescription XIAFLEX®, along with a finger extension procedure, may help straighten or nearly straighten the affected finger and improve range of motion after up to 3 injections.

64%

In one clinical study, 64% of 203 patients (versus 7% of 103 patients receiving placebo) had a straight or nearly straight finger after up to 3 XIAFLEX® injections and finger extension procedures.

44%

In a second clinical study, 44% of 45 patients (versus 5% of 21 patients receiving placebo) had a straight or nearly straight finger after up to 3 XIAFLEX® injections and finger extension procedures.

Since 2010, it is estimated that more than 100,000 patients have been treated with XIAFLEX®.*

*Through May 2017.

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Important Safety Information for XIAFLEX®

Do not receive XIAFLEX® if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®.

XIAFLEX® can cause serious side effects, including:

  • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX® may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit
  • Nerve injury or other serious injury of the hand. Call your healthcare provider right away if you get numbness, tingling, increased pain, or tears in the skin (laceration) in your treated finger or hand after your injection or after your follow-up visit
  • Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX® because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:
    • hives
    • swollen face
    • breathing trouble
    • chest pain
    • low blood pressure
    • dizziness or fainting
  • Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.

Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

The most common side effects with XIAFLEX® for the treatment of Dupuytren’s contracture include:

  • swelling of the injection site or the hand
  • bruising or bleeding at the injection site
  • pain or tenderness of the injection site or the hand
  • swelling of the lymph nodes (glands) in the elbow or armpit
  • itching
  • breaks in the skin
  • redness or warmth of the skin
  • pain in the armpit

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

What is XIAFLEX®?

XIAFLEX® is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. It is not known if XIAFLEX® is safe and effective in children under the age of 18.

Please see the full Prescribing Information, including Medication Guide.