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Prescription treatment for adults with Dupuytren’s contracture when a “cord” can be felt

WHAT IS DUPUYTREN’S CONTRACTURE?

Dupuytren’s contracture (DC) is a progressive hand condition that can limit how much you can move or straighten your fingers. It is caused by a buildup of collagen under the skin that can form a rope-like cord. The condition can worsen over time.

Development of Dupuytren's contracture

  • Collagen builds up in the hand beneath the surface of the skin
  • Collagen thickens into a rope-like cord and extends from the palm to the finger
  • In time, the tightening cord can make the fingers bend inward towards the palm. This is called contracture (con-TRAK-shur)

Explore nonsurgical XIAFLEX®

Risk factors of Dupuytren's contracture

Some people are more likely to have DC. Below are a few of the risk factors.

Age

Age

People over age 40

Family history of DC

Often runs in families

Smoking

May increase the risk of DC

Gender

Men are more likely to have DC

Family background

People with ancestors from Northern Europe

Diabetes

Also believed to increase the risk of DC

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Important Safety Information for XIAFLEX®

Do not receive XIAFLEX® if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®.

XIAFLEX® can cause serious side effects, including:

  • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX® may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit
  • Nerve injury or other serious injury of the hand. Call your healthcare provider right away if you get numbness, tingling, increased pain, or tears in the skin (laceration) in your treated finger or hand after your injection or after your follow-up visit
  • Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX® because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:
    • hives
    • swollen face
    • breathing trouble
    • chest pain
    • low blood pressure
    • dizziness or fainting
  • Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.

Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

The most common side effects with XIAFLEX® for the treatment of Dupuytren’s contracture include:

  • swelling of the injection site or the hand
  • bruising or bleeding at the injection site
  • pain or tenderness of the injection site or the hand
  • swelling of the lymph nodes (glands) in the elbow or armpit
  • itching
  • breaks in the skin
  • redness or warmth of the skin
  • pain in the armpit

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

What is XIAFLEX®?

XIAFLEX® is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. It is not known if XIAFLEX® is safe and effective in children under the age of 18.

Please see the full Prescribing Information, including Medication Guide.