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Prescription treatment for adults with Dupuytren’s contracture when a “cord” can be felt

RECEIVING XIAFLEX®

Understanding the procedure

Considering treatment with XIAFLEX®? The following step-by-step guide can help you get a better grasp on treatment with XIAFLEX®.

Step 1: Injecting XIAFLEX®

Treating Dupuytren’s contracture (DC) with XIAFLEX® is performed in your doctor’s office. Your doctor will:

  • Inject XIAFLEX® directly into the cord that is causing your finger(s) to bend
    • If you have more than 1 contracture, your doctor may give you 2 injections in 1 of your hands during your visit
  • Wrap your treated hand with bandages
  • Advise you to keep your hand elevated until bedtime
  • Advise you to limit the movement of your treated finger(s)

Do not bend or straighten the treated finger(s) yourself.

Call your doctor right away if you have:

  • Signs of infection after your injection, such as fever, chills, increased redness, or swelling
  • Numbness or tingling in the treated finger(s)
  • Trouble bending the injected finger(s) after the swelling goes down
Dupuytren's hand being injected with XIAFLEX®

Step 2: Extending your finger(s)

Your first follow-up visit with your doctor will be approximately 1 to 3 days later. If you still have the cord, your doctor:

  • May try to extend the treated finger(s) and “break” the cord. This is to help straighten your finger(s). Your doctor may use local anesthetic during this procedure

After the extension procedure, your doctor:

  • Will give you a splint to wear on your treated finger(s) at bedtime
  • Will provide simple finger exercises for you to do daily

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Doctor's fingers on Dupuytren's patient's hand

Step 3: Checking your progress

  • Return to your doctor about 30 days later to have your finger(s) examined
  • Depending on your results, or if the cord(s) is still present, you may need additional injections, approximately 4 weeks apart
Doctor checking a patient's hand for Dupuytren's contracture
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Important Safety Information for XIAFLEX®

Do not receive XIAFLEX® if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®.

XIAFLEX® can cause serious side effects, including:

  • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX® may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit
  • Nerve injury or other serious injury of the hand. Call your healthcare provider right away if you get numbness, tingling, increased pain, or tears in the skin (laceration) in your treated finger or hand after your injection or after your follow-up visit
  • Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX® because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:
    • hives
    • swollen face
    • breathing trouble
    • chest pain
    • low blood pressure
    • dizziness or fainting
  • Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.

Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

The most common side effects with XIAFLEX® for the treatment of Dupuytren’s contracture include:

  • swelling of the injection site or the hand
  • bruising or bleeding at the injection site
  • pain or tenderness of the injection site or the hand
  • swelling of the lymph nodes (glands) in the elbow or armpit
  • itching
  • breaks in the skin
  • redness or warmth of the skin
  • pain in the armpit

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

What is XIAFLEX®?

XIAFLEX® is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. It is not known if XIAFLEX® is safe and effective in children under the age of 18.

Please see the full Prescribing Information, including Medication Guide.