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Prescription treatment for adults with Dupuytren’s contracture when a “cord” can be felt

A NONSURGICAL OPTION

Treatment with XIAFLEX®

XIAFLEX® is an FDA-approved, nonsurgical treatment for adults with Dupuytren’s contracture (DC) when a cord can be felt. It starts working as soon as you receive the first injection.

XIAFLEX® is given:

  • In a doctor’s office
  • By a hand specialist with training specifically for XIAFLEX®
  • With no general anesthesia required

DC rarely gets better on its own.

Find a trained hand specialist near you

Since 2010, 100,000 patients have been treated with XIAFLEX®.*

*Based on estimates through May 2017.

XIAFLEX® should be administered by a hand specialist who is trained specifically for injection procedures of the hand and treating people with DC. XIAFLEX® can cause serious side effects such as tendon rupture or ligament damage.

Ask your doctor if XIAFLEX® is right for you

Your doctor may consider treatment with XIAFLEX® if you have:

  • Contractures ranging from less severe to more severe
  • Multiple contractures in 1 hand. Up to 2 cords in 1 hand may be treated during 1 office visit
  • Contractures that have come back. DC may come back no matter what option you use. Nonsurgical XIAFLEX® is available if it returns

Download the Patient Brochure

How XIAFLEX® works

DC is caused by a buildup of collagen under the skin. The collagen may thicken and form a tight, rope-like cord.

XIAFLEX® is injected directly into the cord and works to break it down.

If you still have the cord, your doctor may try to extend the treated finger(s) to "break" the cord and try to straighten your finger(s).

Demonstrated in clinical studies

Studies show that prescription XIAFLEX®, along with a finger extension procedure, may help straighten or nearly straighten the affected finger and improve range of motion after up to 3 injections.

64% circular chart for XIAFLEX®

In one clinical study, 129 out of 203 patients (64%) versus 7 out of 103 patients (7%) receiving placebo had a straight or nearly straight finger after up to 3 XIAFLEX® injections and finger extension procedures.

44% circular chart for XIAFLEX®

In a second clinical study, 20 of 45 patients (44%) versus 1 out of 21 patients (5%) receiving placebo had a straight or nearly straight finger after up to 3 XIAFLEX® injections and finger extension procedures.

Patients in these 2 studies received up to 3 injections of XIAFLEX® or placebo into a cord that could be felt on Days 0, 30, and 60. About 24 hours after each injection, patients had a finger extension procedure and were fitted with a splint to wear at bedtime for up to 4 months. Patients also performed finger exercises every day.

The most common side effects with XIAFLEX® in these studies were swelling of the injected hand and bruising or bleeding at the injection site.

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Important Safety Information for XIAFLEX®

Do not receive XIAFLEX® if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®.

XIAFLEX® can cause serious side effects, including:

  • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX® may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit
  • Nerve injury or other serious injury of the hand. Call your healthcare provider right away if you get numbness, tingling, increased pain, or tears in the skin (laceration) in your treated finger or hand after your injection or after your follow-up visit
  • Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX® because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:
    • hives
    • swollen face
    • breathing trouble
    • chest pain
    • low blood pressure
    • dizziness or fainting
  • Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.

Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

The most common side effects with XIAFLEX® for the treatment of Dupuytren’s contracture include:

  • swelling of the injection site or the hand
  • bruising or bleeding at the injection site
  • pain or tenderness of the injection site or the hand
  • swelling of the lymph nodes (glands) in the elbow or armpit
  • itching
  • breaks in the skin
  • redness or warmth of the skin
  • pain in the armpit

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

What is XIAFLEX®?

XIAFLEX® is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. It is not known if XIAFLEX® is safe and effective in children under the age of 18.

Please see the full Prescribing Information, including Medication Guide.