A NONSURGICAL OPTION
Treatment with XIAFLEX®
XIAFLEX® is an FDA-approved, nonsurgical treatment for adults with Dupuytren’s contracture (DC) when a cord can be felt. It starts working as soon as you receive the first injection.
XIAFLEX® is given:
- In a doctor’s office
- By a hand specialist with training specifically for XIAFLEX®
- With no general anesthesia required
DC rarely gets better on its own.
XIAFLEX® should be administered by a hand specialist who is trained specifically for injection procedures of the hand and treating people with DC. XIAFLEX® can cause serious side effects such as tendon rupture or ligament damage.
Ask your doctor if XIAFLEX® is right for you
Your doctor may consider treatment with XIAFLEX® if you have:
- Contractures ranging from less severe to more severe
- Multiple contractures in 1 hand. Up to 2 cords in 1 hand may be treated during 1 office visit
- Contractures that have come back. DC may come back no matter what option you use. Nonsurgical XIAFLEX® is available if it returns
How XIAFLEX® works
DC is caused by a buildup of collagen under the skin. The collagen may thicken and form a tight, rope-like cord.
XIAFLEX® is injected directly into the cord and works to break it down.
If you still have the cord, your doctor may try to extend the treated finger(s) to "break" the cord and try to straighten your finger(s).
Demonstrated in clinical studies
Studies show that prescription XIAFLEX®, along with a finger extension procedure, may help straighten or nearly straighten the affected finger and improve range of motion after up to 3 injections.
In one clinical study, 129 out of 203 patients (64%) versus 7 out of 103 patients (7%) receiving placebo had a straight or nearly straight finger after up to 3 XIAFLEX® injections and finger extension procedures.
In a second clinical study, 20 of 45 patients (44%) versus 1 out of 21 patients (5%) receiving placebo had a straight or nearly straight finger after up to 3 XIAFLEX® injections and finger extension procedures.
Patients in these 2 studies received up to 3 injections of XIAFLEX® or placebo into a cord that could be felt on Days 0, 30, and 60. About 24 hours after each injection, patients had a finger extension procedure and were fitted with a splint to wear at bedtime for up to 4 months. Patients also performed finger exercises every day.
The most common side effects with XIAFLEX® in these studies were swelling of the injected hand and bruising or bleeding at the injection site.